Deeds from the archives of the State of Macerata show that Verdicchio was cultivated in the surrounding areas of Matelica as far back as 1579. Three elements distinguish the Verdicchio di Matelica from that produced in the Castelli di Jesi area. The first refers to the quantities of grapes produced. The area under vine in Matelica is ten times less than that in Castelli di Jesi. The second element refers to the climatic conditions. The area surrounding Matelica is the only area in the Marches region that runs parallel to the Adriatic coast so that there is no direct link to the sea. Consequently, the climate is continental. The third element which distinguishes this wine is that the enclave of Matelica over the years has produced a particular clone of the Verdicchio vine here as a result of adaptation to the soil and weather conditions which is different from the one used in Jesi.